Vitamin D Status and Systemic Inflammatory Manifestations in Patients with Psoriasis Vulgaris /// Витамин Д статус и системни инфламаторни прояви при пациенти с псориазис вулгарис

Pavlov, Stoyan Ivanov (2016) Vitamin D Status and Systemic Inflammatory Manifestations in Patients with Psoriasis Vulgaris /// Витамин Д статус и системни инфламаторни прояви при пациенти с псориазис вулгарис. Doctoral thesis, Medical University of Varna.

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Official URL: http://eprints.mu-varna.bg/353/

Abstract

[EN] The complex role of vitamin D in the immunopathogenesis of psoriatic disease is genetically determined. In cell culture studies of keratinocytes, an association is described between a genotype risk factor for the development of psoriasis and the suppressed VDR receptor activity regulating epidermal proliferation and differentiation. The association between vitamin D status and the serum level of the human cathelicidin (LL-37) and its presumed role in the initiation of the inflammatory cascade, leading to formation of psoriatic plaques are not well established and proven. Published studies confirm the complex effects of the vitamin D on skin and pathogenic role in psoriasis. Kerato-regulation, immune modulation, suppression of angiogenesis effects of active form of vitamin D could be linked to its genetically-determined metabolic action in glucose and lipid’s homeostasis that have a contribution to the comorbidities in the psoriatic disease. Previously in Bulgaria there are no studies of serum level of vitamin D in patients with psoriasis. The aim of this thesis is to study and analyse the association between vitamin D status and the clinical and laboratory manifestations of Psoriasis Vulgaris in patients with moderate to severe disease activity. The reported study is a first attempt of evaluation of the pathogenic link between vitamin D and human cathelicidin LL-37 in psoriasis. //////////// //////////// [BG] Комплексната роля на вит.Д в имунопатогенезата на псориатичната болест е генетично обусловена. В проучвания върху клетъчни култури от кератиноцити, е описана асоциация, между рисков за развитието на псориазис генотип и подтисната рецепторна активност на VDR, които регулират епидермалната пролиферация и диференциация. Активирането на VDR, води до синтез на антимикробни пептиди, в това число и на кателицидин LL-37. Синтезираният кателицидин LL-37 се свързва с автохтонни ДНК и РНК от апоптотични кератиноцити, активира TLR на АРСs и участва в инициирането на инфламаторната каскада, водеща до образуването на псориатични плаки. Проведеното проучване, за първи в България установява вит.Д статуса на пациенти с псориазис вулгарис, както и анализира връзката му със серумното ниво на антимикробния петид, кателицидин LL-37.

Item Type: Thesis (Doctoral)
Additional Information: Email: stoqan.pavlov@mu-varna.bg; Ch. Assist. Prof. Stoyan Pavlov, MD, PhD, at the Department of Infectious Diseases, Parasitology and Dermatovenereology - ES Dermatovenereology, Medical University of Varna
Uncontrolled Keywords: Psoriasis Vulgaris, vitamin D, cathelicidin (LL-37), pathogenic, keratoregulation
Subjects: R Medicine > RL Dermatology
Divisions: Faculty of Medicine, Health and Life Sciences > School of Medicine
Depositing User: Dr. Stoyan Ivanov Pavlov
Date Deposited: 26 Oct 2017 13:54
Last Modified: 26 Oct 2017 13:55
URI: http://eprints.mu-varna.bg/id/eprint/353

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